Manchester City are a point behind Spurs after a disappointing festive period, with Jurgen Klopp's side able to create a 10-point lead over the reigning champions with victory on Thursday.
It has been billed as one of the biggest games of the Premier League season, with both sets of supporters having an eye on this fixture for weeks.
Whilst a draw for the Reds will be viewed as a positive result, the home side need all three points to close the gap at the top, with manager Pep Guardiola calling it "a big opportunity" to do so.
You can follow all of the action live, including pre-match build-up, in-game commentary and social media reaction, via our match-day blog below.
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Manchester City
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Liverpool
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Live
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January 3, 2019 21:53 UTC
Match ended
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51
2º Half
Liverpool
Throw In
Throw-in for Liverpool at Etihad Stadium.
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2º Half
Liverpool
Throw In
Ball safe as Liverpool is awarded a throw-in in their half.
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50
2º Half
Ederson
Goalkeeper
Yellow card
Ederson for Manchester City has been booked by Anthony Taylor and receives a first yellow card.
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50
2º Half
Manchester City
Goal Kick
Anthony Taylor awards Manchester City a goal kick.
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49
2º Half
Liverpool
Shot Saved
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49
2º Half
Sergio Agüero
Forward
Sergio Agüero of Manchester City smashes in a shot on target. The keeper saves, though.
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48
2º Half
Liverpool
Throw In
Throw-in for Liverpool in the half of Manchester City.
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48
2º Half
Liverpool
Throw In
Liverpool have a dangerous throw-in.
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January 3, 2019 21:50 UTC
89. CHANCE! We could have sealed it! @BernardoCSilva's effort is saved and @sterling7 flashes the rebound wide!!